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專長:CPx-type ATPases 膜蛋白相關研究、銅離子在細胞發育的影響




  1. Tsai, K.-J., K.P. Yoon, and A. R. Lynn, 1992. ATP-dependent cadmium transport by the cadA cadmium resistance determinant in everted membrane vesicles of Bacillus subtilis. Journal of Bacteriology. 174(1):116-121. (SCI)
  2. Tsai, K.-J. and A.L. Linet, 1993. Formation of a phosphorylated enzyme intermediate by the cadA Cd2+ATPase. Arch. Biochem. Biophysics. 305(2):267-70. (SCI)
  3. Tsai, K.-J. 1994 Molecular biology in clinical diagnosis of infectious agents. Medical Technology Bulletin (Chinese) 9(2):11-7.
  4. Liu, G.-R. Wang, T.-Z. Liu and K.-J. Tsai, 1996. Improved fluorometric quantification of urinary xanthurenic acid. Clin. Chem. 42(3):397-401. (SCI)
  5. Tsai, K.-J., L.-Y. Shih, I.-J. Hung, J.-S. Wei, T.Z. Liu, and D.T.Y. Chiu, 1996. Enhanced vesiculation exacerbates complement-dependent hemolysis in glucose-6-phosphate dehydrogenase deficient red cells. Life Sciences 59(10):867-876. (SCI)
  6. Wei, H.C. Cheng, K.-J. Tsai, D.H. Liu, D.T.Y.Chiu, and T.Z. Liu, 1996. Purification and characterization of endogenous digitalis-like compounds in chicken blood. Life Sciences 59(19):1617-1629. (SCI)
  7. Tsai, K.-J., C.-M. Hsu, and B. P. Rosen, 1997. Efflux Mechanisms of Resistance to Cadmium, Arsenic and Antimony in Prokaryotes and Eukaryotes. Zoological Studies 36(1):1-16. (SCI)
  8. Liu, T.Z., Lin, T.F., Chiu, D.T.Y., Tsai, K.-J. and A. Stern, 1997. Palladium or platinum exacerbates hydroxyl radical mediated DNA damage. Free Radical Biology & Medicine 23(1):155-161. (SCI)
  9. Liu, C.-H., C.-C. Yang, M.-H. Wu, K.-J. Tsai and M.-S. Lee 1997. The patterns of originally stored proteins in mouse egg and embryo at different stages during preimplantation. J. Reprod. Infert. 6:147-155. (SCI)
  10. Tsai, K-J. I-J. Hung, C.K. Chow, A. Stern, S.S. Chao and D. T.Y. Chiu. 1998. Impaired production of nitric oxide and hydrogen peroxide in glucose-6-phosphate-dehydrogenase-deficient granulocytes. FEBS Letters, 436:411-414. (SCI)
  11. Pinpin Lin, Hsiu-jen Wang, Huei Lee, Hong-Shen Lee, Shu-Li Wang, Yu-Mei Hsueh, Kan-Jen Tsai, Chih-Yi Chen. 1999. NAD(P)H: Quinone oxidoreductase polymorphism and lung cancer in Taiwan. Journal of Toxicology and Environmental Health, Part A, 58:187-197. (SCI)
  12. P. Lin, S.-L Wang, H-J Wang, K-W Chen, H-S Lee, Kan-Jen Tsai, C-Y Chen and H Lee. 1999. Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma. British Journal of Cancer, 82(4):852-857. (SCI)
  13. S.-L Wang, H. Lee, K-W. Chen, Kan-Jen Tsai, C-Y. Chen. Pinpin Lin. 1999. Cytochrome P4502E1 genetic polymorphisms and lung cancer in a Taiwanese population. Lung Cancer, 26:27-34. (SCI)
  14. Hsueh-Hsia Lo, Sue-Er Hsieh, Kan-Jen Tsai, and Jing Gung Chung. 1999. The effects of ellagic acid on arylamine N-acetyltransferase activity in the bacterium Pseudomonas aeruginosa. Drug and Chemical Toxicology, 22(3):555-562. (SCI)
  15. Fang, M., Majumder, A., Tsai, K.-J., and Wu, H.-Y. 2000. ppGpp-dependent leuO expression in bacteria under stress. Biochemical and Biophysical Research Communications, 276(1):64-70. (SCI).
  16. Arundhati Majumder, Ming Fang, Kan-Jen Tsai, Chiharu Ueguchi, Takeshi Mizuno, and Hai-Young Wu. 2001. LeuO Expression in Response to Starvation for Branched-Chain Amino Acids. Journal of Biological Chemistry. 276(22):19046-19051. (SCI).
  17. Kan-Jen Tsai, Yung-Feng Lin, Marco D. Wong, Henry Hung-Chi Yang, Hsueh-Liang Fu and Barry P. Rosen. 2002. Membrane topology of the pI258 CadA Cd(II)/Pb(II)/Zn(II)- translocating P-type ATPase. Journal of Bioenergetics and Biomembranes 34(3): 147-156. (SCI)
  18. Sheau-yun Yuan, Shih-Lan Hsu, Kan-Jen Tsai, Chi-Rei Yang. 2002. Involvement of mitochondrial pathway in Taxol-induced apoptosis of human T24 bladder cancer cells. Urological Research 30(5):282-8 (SCI)
  19. Pinpin Lin, Yu-Mei Hsueh, Jiunn-Liang Ko, Yu-Fei Liang, Kan-Jen Tsai, Chih-Yi Chen. 2003. Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan. Lung Cancer 40:123-129. (SCI)
  20. Chung-Hsien Liu, David PC Lin, Chung-Chie Yang, Meng-Hsi Wu, and Kan-Jen Tsai. 2004. Stored HSP70/HSC70 in mouse egg and embryo at different stages during preimplantation. Reprod. Dom. Anim. 39:1-6 (SCI)
  21. Shiau MY, Tsai ST, Tsai Kan-Jen, Haung ML, Hsu YT, Chang YH. 2006. Increased circulatory MMP-2 and MMP-9 levels and activities in patients with type 1 diabetes mellitus. Mount Sinai Journal of Medicine. 73:1024-1028 (SCI)
  22. Shiau MY, Huang CN, Yang TP, Hwang YC, Tsai Kan-Jen, Chi CJ, Chang YH. 2007. Cytokine promoter polymorphisms in Taiwanese patients with Graves’ disease. Clinical Biochemistry 40:213-217 (SCI)
  23. Liu CH, Huang LJ, Kuo SC, Lee TH, Tsai Kan-Jen, Chan HC. 2009. 4-Fluoro-N-butylphenyl acetamide (H6) inhibits cell growth via cell-cycle arrest and apoptosis in human cervical cancer cells. Bioorganic & Medicinal Chemistry 17:42–48. (SCI) 
  24.  Hong-Ru Chen, Hung-Chi Yang, Dennis Jine-Yuan Hsieh, Zijuan Liu, Kan-Jen Tsai. 2011 Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. Chemico-Biological Interactions 189:192-197 (SCI) 
  25.  Lin Shiau Yuan, Hung-Chi Yang, Dennis Jine-Yuan Hsieh, David Lin, Tsai Kan-Jen. 2011. Sox-10 regulation mediated by copper-dependent Atox-1 expression: A new role for copper chaperon Atox-1 (in preparation)
  26. Guan-Yu Chen, Hung-Chi Yang, Dennis Jine-Yuan Hsieh, Zijuan Liu, Kan-Jen Tsai. 2011. ABCG2 mediates hemopoiesis through regulations of SCL and Gata genes in Zebrafist embryo (in preparation)










  1. 蔡淦仁 2003年七月 “分子檢驗”專書 (第3章 分子檢驗基本技術 pp. 32-55)出版單位:教育部顧問室-生物技術科技教育改進計畫
  2. 蔡淦仁李名世監修,叢玉隆、秦小玲、鄧新立主編,醫學實驗是管理:原理與實用 合記圖書出版2008年十月