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  5. 林培正老師

林培正老師

專任教師

 

 

姓名：林培正
職稱：教授
學歷：博士：英國愛丁堡大學醫學院胚胎學
          碩士：澳大利亞Monash大學生殖學研究所
          學士：中山醫學院醫技系
聯絡電話：04-24730022 #12405
E-Mail：pcl@csmu.edu.tw
專長：幹細胞與抗老化　視覺保健生物技術
教授科目：生殖細胞及幹細胞生物醫學 

 

 

期刊論文-----期刊論文

 

1.      Dietary alpha-lipoic acid prevents UVB-induced corneal and conjunctival degeneration through multiple effects. Chen BY, Lin DP, Huang TP, Chang LS, Liu HJ, Luk CP, Lo YL, Chang HH. Investigative Ophthalmology & Vision Science. 2013. (accepted)
2.      Assessment of UVB-blocking effects by weekly disposable contact lenses in a mouse model. Lin DP, Chang HH, Yang LC, Huang TP, Liu HJ, Chang LS, Lin CH, Chen BY. Mol Vis 2013. 19:1158-1168.
3.      Characterising visual deficits in children of an urban elementary school in Taiwan.Cheng HM, Sun HY, Lin DP, Chang HH, Chen ST, Yeh SM, Peng ML, Tseng JK, Su KC, Tseng KW, Chen BY, Hsiao CJ, Huang SY, Cheng CY. Clin Exp Optom. 2012. 95(5):531-7.
4.      Curcumin alleviates eosinophilic meningitis through reduction of eosinophil count following albendazole treatment against Angiostrongylus cantonensis in mice. Shyu LY, Chang HH, Hsu JD, Lin DP, Teng YH, Lee HH. Parasitology. 2012. 139(3):358-65.
5.      Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro. Shyu LY, Yeh TM, Chang HH, Lin DP, Teng YH, Chen LC, Lee HH.Thromb Res. 2012. 129(1):43-9.
6.      Intravitreal homocysteine-thiolactone injection leads to the degeneration of multiple retinal cells, including photoreceptors. Chang HH, Lin DP, Chen YS, Liu HJ, Lin W, Tsao ZJ, Teng MC, Chen BY. Mol Vis. 2011. 17:1946-1956.
7.      Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation. Chen BY, Lin DP, Wu CY, Teng MC, Sun CY, Tsai YT, Su KC, Wang SR, Chang HH. Mol Vis. 2011. 17:854-63.
8.      Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse. Chen BY, Lin DP, Su KC, Chen YL, Wu CY, Teng MC, Tsai YT, Sun CY, Wang SR, Chang HH. Mol Vis. 2011. 17:723-30.
9.      Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model. Chang HH, Chen BY, Wu CY, Tsao ZJ, Chen YY, Chang CP, Yang CR, Lin DP. J Biomed Sci. 2011. 18:6-18.
10.   Basic Concepts of Normal Stereoptic Images Formation andPathologic Influences of 3D Monitors on Human Eyes. Ying-Shan Chen, David P Lin, Bo-Yie Chen, Lin-Song Chang. Optical Engineering. 2011. 116: 22-31.
11.   Sonic Hedgehog improves in vitro development of porcine parthenotes and handmade cloned embryos. Nguyen NT, Lin DP, Siriboon C, Lo NW, Ju JC. Theriogenology. 2010. 74(7):1149-60.
12.   Sensory and Sympathetic Denervation in the Foot Pads of Mice with a Defect in Bullous Pemphigoid Antigen 1 (BPAG1) Gene. Hung-Yu Li, David P Lin, Chin-Yin Chen, Ko-Kaung Liao, Chun-Lan Liu, Mei-Lin Peng, Yang-Cheng Wen, Kuang-Wen Tseng. Chung Shan Medical Journal. 2010. 21(2), 189-199.
13.   Comparing Heterophoria with Three Measuring Methodologies. Lung-Fei Chai, David P Lin, Jimmy Su, Shyan-Tarng Chen. Chung Shan Medical Journal. 2010. 21(3), 275-284.
14.   Congenital eye malformations associated with extensive periocular neural crest apoptosis after influenza B virus infection during early embryogenesis. BY Chen, HH Chang, SY Chen, ZJ Tsao, SM Yeh, CY Wu, Lin DP. Mol Vis. 2009. 15, 2821-2828.
15.   Sonic Hedgehog promotes porcine oocyte maturation and early embryo development. Nguyen NT, Lin DP, Yen SY, Tseng JK, Chuang JF, Chen BY, Lin TA, Chang HH, and Ju JC. Reprod Fertil Dev. 2009. 21(6): 805-815.
16.   Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart. Hwang JM, Weng YJ, Lin JA, Bau DT, Ko FY, Tsai FJ, Tsai CH, Wu CH, Lin DP, Huang CY, Kuo WW. Mol Cell Biochem. 2008. 311(1-2):179-87.
17.   Tseng SS, Lin DP. The mathematics of optometry - the optometrist’s reference for clinical optics equations and calculations, part I: power and curvature. Clinical & Refractive Optometry. 2007, 18, 225-229.
18.   Hedgehog is involved in prostate basal cell hyperplasia formation and its progressing towards tumorigenesis. Chen BY, Liu JY, Chang HH, Chang CP, Lo WY, Kuo WH, Yang CR, Lin DP. Biochem Biophys Res Commun. 2007. 357(4):1084-9.
19.   A mouse prostate cancer model induced by Hedgehog overexpression. Chen BY, Lin DP, Liu JY, Chang H, Huang PH, Chen YL, and Chang HH. J Biomed Sci. 2006. 13(3):373-384.
20.   Sperm DNA fragmentation correlates with velocity and fertilization rates but might not affect pregnancy rates. CC Hunag, DP Lin, HM Tsao, TC Cheng, CH Liu, MS Lee. Fertility & Sterility. 2005. 84 (1);130-140.
21.   Comparison of mitochondrial DNA contents in human embryos with good or poor morphology at 8-cell stage. DP Lin, CC Huang, HM Wu, Cheng TC, Chen CI, Lee MS. Fertility & Sterility. 2004. 18:3-79.
22.   Influenza B virus-induced malformations in the eye and brain during early chick embryogenesis and localization of the viral RNA in specific areas. BY Chen, HH Chang, CH Ling, and DP Lin. Journal of Biomedical Science. 11:266-274, 2004.
23.   Store of Hsp72/Hsp73 in germinal vesicle (GV)-stage mouse oocytes. Liu CH, Yang CC, Lin DP, Wu MS, Tsai KJ. Reproduction in Domestic Animals. 39:19-24, 2004.
24.   DNA fragmentation, mitochondria dysfunction, and chromosomal aneuploidy in the spermatozoa of oligoathenoteratozoospermic males. CH Liu, HM Tsao, TC Cheng, HM Wu, CC Huang, CI Chen, DP Lin, MS Lee. J of Assist Reprod and Genetics. 2004. 21:119-126.
25.   Male germ line stem cells: from cell biology to cell therapy. DP Lin, M-Y Chang, B-Y Chang, H-H Chang. Reprod Fertil and Develop. 2003. 15:323-331.
26.   Developmental analysis of the Hba(th-J) mouse mutation: effects on mouse peri-implantation development and identification of two candidate genes.Hendrey J, Lin D, Dziadek M. Dev Biol. 1995. 172(1):253-63

 

期刊論文-----研討會論文

 

  1. Han-Hsin Chang, Shang-Je Tasi, Wei-Yu Luo, Yi-Ying Li, Chu-Chyn Ou, Bo-Yie Chen, David PC Lin (2006) Mouse fatty liver disease model induced by corn oil reflects a crouch-jump transit of total body weight, total liver weight and white adipose weight (台灣食品科學技術學會第三六次年會 2006 Taiwan Association for Food Science and Technology，國立海洋大學，基隆，台灣)
  2. Yie-Ling Chen, Han-Hsin Chang, Bo-Yie Chen, Jan-Fu Chen, Zhao-Tung Ding, Yu-Hsiung Chang, Wei-Yu Luo, David PC Lin (2006) Hedgehog signaling plays an inhibitory role during adipocyte differentiation (台灣食品科學技術學會第三六次年會 2006 Taiwan Association for Food Science and Technology，國立海洋大學，基隆，台灣)
  3. Wei-Ru Chen, Lih-Geeng Chen, Chin-Pao Chang, David PC Lin, Bo-Yie Chen, Han-Hsin Chang (2006) -mangostin and -mangostin inhibit in vitro and in vivo prostate cancer cell growth through down-regulation of Hedgehog signaling pathway (台灣食品科學技術學會第三六次年會 2006 Taiwan Association for Food Science and Technology，國立海洋大學，基隆，台灣)
  4. Lih-Geeng Chen, Wei-Ru Chen, Chi-Rei Yang,  David PC Lin, Bo-Yie Chen, Han-Hsin Chang  (2006) Screening of 21 natural products of their growth inhibitory effects on human prostate cancer (台灣食品科學技術學會第三六次年會 2006 Taiwan Association for Food Science and Technology，國立海洋大學，基隆，台灣)
  5. 余俊賢 陳伯易 蕭元超 林培正 張菡馨 陳億乘(2006) 葡萄醛酸內酯(glucuronolactone)對ICR鼠胚胎發育的影響 (台灣食品科學技術學會第三六次年會2006 Taiwan Association for Food Science and Technology，國立海洋大學，基隆，台灣)
  6. Pei-Cih Kang , Bo-Yie Chen ,Wu-Sian Guo , Mei-Hua Lin , David P.C. Lin , Han-Hsin Chang (2007) Human colon cancer stem cell CD133 and CD44 expression and its relation to the Hedgehog signaling pathway (第一屆國際癌症學術研討會 The 1st International Cancer Symposium  2007年11月16~17日，中國醫藥大學，台中，台灣)
  7. Zhao-Tung Ting, Yu-Hsuan Chang, Bo-Yie Chen, Chin-Po Chang, David Pei-Cheng Lin, Han-Hsin Chang (2007) Hedgehog signaling is inversely related to androgen receptor expression in the human prostate cancer stem cells (第一屆國際癌症學術研討會 The 1st International Cancer Symposium  2007年11月16~17日，中國醫藥大學，台中，台灣)
  8. Yu-Hsuan Chang, Zhao-Tung Ting, Bo-Yie Chen, Chi-Rei Yang, David Pei-Cheng Lin, Han-Hsin Chang (2007) A mouse prostate cancer model affected by Androgen and Hedgehog Protein (第一屆國際癌症學術研討會 The 1st International Cancer Symposium  2007年11月16~17日，中國醫藥大學，台中，台灣)
  9. Pi-Ying Tai, Bo-Yie Chen, Jian-Fu Chen, David P.C. Lin, Han-Hsin Chang (2007) Effect of Hedgehog pathway on fat formation in HepG2 and 3B human hepatocellular carcinoma cell lines (第一屆國際癌症學術研討會 The 1st International Cancer Symposium  2007年11月16~17日，中國醫藥大學，台中，台灣)
  10. Pei-Cih Kang , Bo-Yie Chen , Yi-Jhen Li , Siao-Ting Hong , Chin-Pao Chang , Zhao-Tung Ting ,Yu-Hsuan Chang , Han-Hsin Chang , David Pei-Cheng Lin (2007) Hedgehog as a prostate cancer marker: a clinical assessment. (台灣蛋白體學會年會暨國際研討會 Taiwan Proteomics Society International Conference 2007年12月4~5日，國立成功大學，台南，台灣)
  11. 蔡尚哲 曾廣文 張菡馨 林培正 陳伯易 丁肇彤 (2007) 以小鼠模式探討初期非酒精性脂肪肝病程發展並以EGCG作為嘗試性治療成果 (台灣食品科學技術學會第三七次 2007 Taiwan Association for Food Science and Technology，大葉大學，彰化，台灣)
  12. Bo-Yie Chen, Rei-Fan Zwang, Shyan-Tang Chen, Yo-Yie Lin, James Yie-Jie Jam, Han-Hsin Chang, David Pei-Cheng Lin  (2008) Evaluation of Early Fetal Head Surface Ectoderm as a Corneal Repair Source (2008 International Conference on Biomedicine, China Medical University, 01-02 May, Taichung, Taiwan) (2008國際醫學研究研習會，中國醫藥大學，2008年5月1、2日，台中)
  13. Bo-Yie Chen, Rei-Fan Zwang, Shyan-Tang Chen, Yo-Yie Lin, James Yie-Jie Jam, Han-Hsin Chang, David Pei-Cheng Lin  (2008) Hedgehog Promotes Limbal Stem Cell Proliferation, but Not Migration and Terminal Differentiation of Corneal Epithelium (2008 International Conference on Biomedicine, China Medical University, 01-02 May, Taichung, Taiwan) (2008國際醫學研究研習會，中國醫藥大學，2008年5月1、2日，台中)
  14. Bo-Yie Chen, David Pei-Cheng Lin, Han-Chien Yang, Pei-Wen Chen, Hsiao-Ting Hung, Ya-Hsuan Lin, Han-Hsin Chang Hedgehog Activation Leads to Expansion of a Prostatic Stem/Progenitor Cell Subpopulation leading to Tumor Initiation, Neoplasia and Metastasis.(The 9th Development Biology Retreat IMB, 國立中興大學,September 5-6, 2008 )
  15. Bo-Yie Chen, Shyan-Tang Chen, Rei-Fan Zwang, Sheng-De Wang, Ming-Chieh Lin, Han-Hsin Chang, David Pei-Cheng Lin (2008) Hedgehog Promotes Limbal Stem Cell Proliferation and Re-epithelialization in the Alkali-burned Mouse Cornea. (The 9th Development Biology Retreat IMB, 國立中興大學,September 5-6, 2008 )