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姓名: 謝錦源
職稱: 助理教授
學歷: 博士: 國防醫學院生命科學研究所
    碩士: 陽明大學生理所
    學士: 高雄醫學院醫技系
聯絡電話: 04-24730022 #12384
專長: 發育生物學、細胞生物學、分子生物學




  1. Chen MC, Lee NH, Hsu HH, Ho TJ, Tu CC, Hsieh DJ, Lin YM, Chen LM, Kuo WW, Huang CY. Thymoquinone Induces Caspase-Independent, Autophagic Cell Death in CPT-11-Resistant LoVo Colon Cancer via Mitochondrial Dysfunction and Activation of JNK and p38. J Agric Food Chem. 2015 63(5): 1540-6.
  2. Hsieh DJ, Huang CY, Pai PY, Wang PS, Tsai YL, Li CN, Kuo WW, Huang CY. Prolactin protects cardiomyocytes against intermittent hypoxia-induced cell damage by the modulation of signaling pathways related to cardiac hypertrophy and proliferation. International Journal of Cardiology. 2015 181: 255-266.  
  3. Huang CY, Kuo WW, Kuo CH, Tsai FJ, Liu PY and Hsieh DJ*. Protective effect of Danggui (Radix Angelicae Sinensis) on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells. BMC Complement Altern Med. 2014 14: 358-367.
  4. Weng YS, Kuo WW, Lin YM, Kuo CH, Tzang BS, Tsai FJ, Tsai CH, Lin JA, Hsieh DJ  and Huang CY. Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts. Food Chem Toxicol. 2013 56: 28-39.
  5. Chou SH, Lin SZ, Day CH, Kuo WW, Shen CY, Hsieh DJ, Lin JY, Tsai FJ, Tsai CH and Huang CY. Mesenchymal stem cell insights: prospects in hematological transplantation. Cell Transplant. 2013 22(4): 711-721.
  6. Tsai CY, Lai CH, Chang MH, Jong GP, Cheng YC, Tsai FJ, Tsai CH, Kuo WH, Hsieh DJ and Huang CY. IGF-II and MMP9 as surgical repair indicators of ventricular septal defects. Clin Chim Acta. 2011 412(9-10): 761-765.
  7. Chen HR, Yang HC, Hsieh DJ, Liu Z and Tsai KJ. Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. Chem Biol Interact. 2011 189(3): 192-197.
  8. Weng YJ, Kuo WW, Kuo CH, Tung KC, Tsai CH, Lin JA, Tsai FJ, Hsieh DJ*, Huang CY* and Hwang JM*. BNIP3 induces IL6 and calcineurin/NFAT3 hypertrophic-related pathways in H9c2 cardiomyoblast cells. Mol Cell Biochem. 2010 345(1-2): 241-247.
  9. Weng YJ, Hsieh DJ, Kuo WW, Lai TY, Hsu HH, Tsai CH, Tsai FJ, Lin DY, Lin JA, Huang CY and Tung KC. E4BP4 is a cardiac survival factor and essential for embryonic heart development. Mol Cell Biochem. 2010 340(1-2): 187-194.
  10. Ye JC, Chang WC, Hsieh DJ and Hsiao MW. Extraction and analysis of β-sitosterol in herbal medicines. Journal of Medicinal Plants Research. 2010 4(7): 522-527.
  11. Wu HC, Yeh YL, Kuo WW, Huang SK, Kuo WH, Hsieh DJ, Wu CL, Tsai CH, Lee SD and Huang CY. P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium. Cell Biochem Funct. 2008 26(2): 246-255.
  12. Chan CR, Lee DN, Cheng YH, Hsieh DJ, and Weng CF. Feed Deprivation and Re-feeding on Alterations of Proteases in Tilapia Oreochromis mossambicus. Zoological Studies. 2008 47(2): 207-214.
  13. Jong GP, Wang YF, Tsai FJ, Tsai CH, Wu CL, Liu RH, Hsieh DJ, Ko FY, Huang CY and Lee SD. Immunoglobulin E and matrix metalloproteinase-9 in patients with different stages of coronary artery diseases. Chin J Physiol. 2007 50(6): 277-282.
  14. Chien EJ, Liao CF, Chang CP, Pu HF, Lu LM, Shie MC, Hsieh DJ and Hsu MT. 2007. The Non-genomic effects on Na+/H+-exchange 1 by progesterone and 20α-hydroxyprogesterone in human T cells. J Cell Physiol. 2007 9999: 1-8.
  15. Kuo WW, Chu CY, Wu CH, Lin JA, Liu JY, Hsieh YH, Ueng KC, Lee SD, Hsieh DJ, Hsu HH, Chen LM and Huang CY. Impaired IGF-I signalling of hypertrophic hearts in the developmental phase of hypertension in genetically hypertensive rats. Cell Biochem Funct. 2005 23: 325-331.
  16. Chen MH, Lin GH, Gong HY, Hsieh DJ, Lin CJ and Wu JL. Functional analysis of the insulin-like growth factor 1 receptor gene promoter in the zebrafish (Danio rerio). Marine Biotechnology. 2004 6: S146-S152. (SCI)
  17. Hsieh DJ and Liao CF. Zebrafish M2 Muscarinic Acetylcholine Receptor: Cloning, Pharmacological Characterization, Expression Patterns and Roles in Embryonic Bradycardia. British Journal of Pharmacology 2002 137: 782-792.
  18. Chien EJ, Hsieh DJ and Wang EC. Response of Alkalinization or Acidification by Phytohemagglutinin is Dependent on the Activity of Protein Kinase C in Human Peripheral T Cells. Journal of Cellular Biochemistry 2001 81: 604-612.
  19. Chien EJ, Chien CH, Chen JJ, Wang SW, and Hsieh DJ. Bacterial Lipopolysaccharide Activates Protein Kinase C, but Not Intracellular Calcium Elevation, in Human Peripheral T Cells. Journal of Cellular Biochemistry 2000 76: 404-410.





  1. Kuo WW, Hsieh DJ, Huang CY, Huang CY. Inhibition TGF-β Pathway to Prevent Cardiac Fibrosis of SHSST Cyclodextrin Complex on Cirrhotic-Cardiomyopathy Rat Hearts. 2014, International Scientific Conference on Engineering and Applied Sciences. August 15-16, 2014, Singapore.  
  2. Hsieh YT, Wu JB, Tsai KJ, Hsieh DJ#. Alkaline Phosphatase Mediate Macrophages Differentiation on Zebrafish. 2014, The 29th Joint Annual Conference of Biomedical Sciences. Taipei.
  3. Lee TH, Hsu JW, Hsu ST, Lin YX, Jhuang WS, Hsieh DJ#. Effects of Alkaline Phosphatases on Macrophage. 2011, The 26th Joint Annual Conference of Biomedical Sciences. Taipei.
  4. Ho PJ, Chen WC and Hsieh DJ#. Role of alkaline phosphatase in regulation of pronephron development and segmentation in zebrafish. 2009, The 24th Joint Annual Conference of Biomedical Sciences. Taipei.
  5. Chang CF, Liu CK, Yang YT, Chen YH, Lin H, Hsieh DJ and Tsai JN. Depletion of rspo3 suppresses Wnt/β-catenin signaling during zebrafish embryogenesis. 2009, The 24th Joint Annual Conference of Biomedical Sciences. Taipei, R.O.C. Abs#P570.
  6. Su QZ, Hsieh DJ#, Chen WC, Huang CY, Yang JJ, Chu CH, Lin JA and Huang CH. Function of E4BP4 gene on zebrafish embryogenesis. 2006, Programs and Abstracts P418 (p. 207).
  7. Hsu LS, Lee HM, Hsieh DJ and Lee HC. Isolation and expression pattern of zebrafish FOXO5 gene. 2006, Programs and Abstracts P437 (p. 212)
  8. Chen WC, Hsu LS and Hsieh DJ#. Roles of alkaline phosphatase on zebrafish embryogenesis. 2006, Programs and Abstracts P573 (p. 250)
  9. Chen MH, Gong HY, Hsieh DJ, Lin CJ, Lin GH and Wu JL. The insulin-like growth factor 2 involve in thorax development in zebrafish (Danio rerio). 2003, In: The Sixth Asia-Pacific Marine Biotechnology Conference. Japan, September 21-27, Abstract S3-1C-2, pp.28.
  10. Lin GH, Chen MH, Gong HY, Hsieh DJ, Lin CJ and Wu JL. Regulation of insulin-like growth factor 1 receptor gene promoter in the zebrafish. 2003, In: The Sixth Asia-Pacific Marine Biotechnology Conference. Japan, September 21-27, Abstract P1-078, pp.148.
  11. Lin GH, Chen MH, Gong HY, Hsieh DJ, Lin CJ, Weng CF and Wu JL. The Insulin-like Growth Factor 1, Insulin-like Growth Factor 2 and Their Receptor Involve in Thorax Development in Zebrafish (Danio rerio). 2002, 16th FAOBMB Symposium.
  12. Hsieh DJ and Liao CF. Development of Zebrafish Cardiac Negative Chronotropism. 2001, International Marine Biotechnology Symposium.
  13. Jine-Yuan Hsieh, Hsin-Tien Huang, Mark Hung-Chih Chen , Ching-Feng Weng, Jen-Leih Wu and Ching-Fong Liao . Roles of M2 Muscarinic Acetylcholine Receptor in Zebrafish Development. 2000, Zebrafish Development & Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.  
  14. Jine-Yuan Hsieh and Ching-Fong Liao. Expression of M2 Muscarinic Acetylcholine Receptor mRNA in Zebrafish Embryo. 2000, The Fifteenth Joint Annual Conference of Biomedical Sciences, Taipei , March 25-26, Programs and Abstracts #313 (p. 242).