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林慧萱老師

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姓名：林慧萱
職稱：副教授
學歷：博士： 中山醫學大學生化暨生物科技研究所博士
學士：中山醫學大學醫事技術學系學士
聯絡電話：04-24730022 #12410
E-Mail：Linhh@csmu.edu.tw
專長：癌症生化、疾病化學預防、細胞訊息傳遞
教授科目：生物技術學、分子生物學、癌生物學

 

期刊論文------期刊論文

 

 

  1. Hui-Hsuan Lin*. In vitro and in vivo atheroprotective effects of gossypetin against endothelial cell injury by induction of autophagy. Chemical Research in Toxicology 28, 202-285, 2015. [Impact factor: 4.190; Ranking: 5/58] (NSC 99-2632-B-040-001-MY3)
  2.  Shu-Huan Wu, Charng-Cherng Chyau, Jing-Hsien Chen, Shu-Fen Tu, Hui-Hsuan Lin*, Fen-Pi Chou*. Anti-cancerous effects of Wasabia japonica extract in Hep3B liver cancer cells via ROS accumulation, DNA damage and p73-mediated apoptosis. Journal of Functional Foods. 14, 445-455, 2015. [Impact factor: 4.480; Ranking: 5/123] (NSC 99-2632-B-040-001-MY3)
  3. Chun-Tang Chiu, Shu-Wen Hsuan, Hui-Hsuan Lin, Cheng-Chin Hsu, Fen-Pi Chou, Jing-Hsien Chen (2014, Dec). Hibiscus sabdariffa leaf polyphenolic extract induces human melanoma cell death, apoptosis and autophagy. Journal of Food Science. 80, H649-H658, 2015. [Impact factor: 1.791; Ranking: 45/123] (NSC 99-2303-B-040-015-MY3)
  4. Hui-Hsuan Lin, Ming-Der Shi, Hsien-Chun Tseng, Jing-Hsien Chen*. Andrographolide sensitizes the cytotoxicity of human colorectal carcinoma cells toward cisplatin via enhancing apoptosis pathways in vitro and in vivo. Toxicological Sciences. 139, 108-120, 2014. [Impact factor: 4.478; Ranking: 10/87] (NSC 97-2313-B-173-002)
  5. Zhi-Hong Wang, Cheng-Chin Hsu, Hui-Hsuan Lin*, Jing-Hsien Chen*. Anti-diabetic effects of Carassius auratus complex formula in high fat diet combined streptozotocin-induced diabetic mice. Evidence-Based Complementary and Alternative Medicine, 2014, 628473, 2014. [Impact factor: 2.175; Ranking: 6/22] (NSC 102-2622-B-040-002-CC3)
  6. Jing-Hsien Chen, Chia-Wen Tsai, Chi-Ping Wang, Hui-Hsuan Lin*. Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation. Toxicology and Applied Pharmacology. 272, 313-324, 2013. [Impact factor: 3.630; Ranking: 16/87] (NSC 99-2632-B-040-001-MY3)
  7. Jing-Hsien Chen, Chau-Jong Wang, Jenn-Yuan Sheu, Hui-Hsuan Lin*. Hibiscus sabdariffa leaf polyphenolic extract inhibits LDL oxidation and foam cell formation involving up-regulation of LXRa/ABCA1 pathway. Food Chemistry. 141, 397-406, 2013. [Impact factor: 3.259; Ranking: 10/123] (NSC 99-2632-B-040-001-MY3)
  8. Ming-Der Shi, Jing-Hsien Chen, Hsin-Te Sung, Jung-Shin Lee, Li-Yu Tsai, Hui-Hsuan Lin*. CXCL12-G801A polymorphism modulates risk of colorectal cancer in Taiwan. Archives of Medical Science. 9, 999-1005, 2013. [Impact factor: 1.067; Ranking : 79/155]
  9. Hui-Hsuan Lin, Kuei-Chuan Chan, Jenn-Yuan Sheu, Shu-Wen Hsuan, Chau-Jong Wang*, Jing-Hsien Chen*. Hibiscus sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo. Food Chemistry. 132, 880-891, 2012. [Impact factor: 3.259; Ranking: 10/123] (NSC 98-2313-B-040-003-MY3)
  10. Chia-Wen Tsai, Chia-Yuan Lin, Hui-Hsuan Lin, Jing-Hsien Chen. Carnosic acid, a rosemary phenolic compound, induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells. Neurochemical Research. 36, 2442-2451, 2011. [Impact factor: 2.125 ; Ranking: 169/251]
  11. Hui-Hsuan Lin, Chia-Wen Tsai, Fen-Pi Chou, Chau-Jong Wang, Shu-Wen Hsuan, Cheng-Kun Wang, Jing-Hsien Chen*. Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells. Toxicology and Applied Pharmacology. 250, 336-345, 2011. [Impact factor: 3.975; Ranking: 12/85] (NSC 97-2313-B-273-002)
  12. Hui-Hsuan Lin, Jing-Hsien Chen, Fen-Pi Chou, Chau-Jong Wang*. Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation. British Journal of Pharmacology. 162, 237-254, 2011. [Impact factor: 5.067; Ranking: 21/260] (NSC 94-2320-B-040-046) 
  13. Hui-Hsuan Lin, Jing-Hsien Chen, Chau-Jong Wang*. Chemopreventive properties and molecular   mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne. Current Medicinal Chemistry. 18, 1245-1254, 2011. [Impact factor: 4.070; Ranking: 5/59] (NSC 92-2745-B-040-001)
  14. Yi-Chieh Lee, Hui-Hsuan Lin, Chin-Hsun Hsu, Chau-Jong Wang, Tai-An Chiang, Jing-Hsien Chen*. Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway. European Journal of Pharmacology. 632, 23-32, 2010. [Impact factor: 2.592; Ranking: 105/260] (NSC 96-2320-B-273-003)
  15. Ming-Der Shi, Hui-Hsuan Lin, Tai-An Chiang, Li-Yu Tsai, Shu-Mei Tsai, Yi-Chieh Lee, Jing-Hsien Chen*. Andrographolide could inhibit human colorectal carcinoma Lovo cells migration and invasion via down-regulation of MMP-7 expression. Chemico-Biological Interactions. 180, 344-352, 2009. [Impact factor: 2.967; Ranking: 75/260]
  16. Jing-Hsien Chen, Hui-Hsuan Lin, Tai-An Chiang, Jeng-Dong Hsu, Hsieh-Hsun Ho, Yi-Chieh Lee, Chau-Jong Wang*. Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion and metastasis via iNOS-mediated MMP-2 production. Toxicological Sciences. 106, 364-375, 2008. [Impact factor: 4.328; Ranking: 8/85] (NSC 95-2320-B-040-021)
  17. Ming-Der Shi, Hui-Hsuan Lin, Yi-Che Lee, Jian-Kang Chao, Rong-An Lin, Jing-Hsien Chen*. Inhibition of cell cycle progression in human colon carcinoma Lovo cells by andrographolide. Chemico-Biological Interactions. 174, 201-210, 2008. [Impact factor: 2.967; Ranking: 75/260]
  18. Hui-Hsuan Lin, Jing-Hsien Chen, Chi-Chou Huang, Chau-Jong Wang*. Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation. International Journal of Cancer. 120, 2306-16, 2007. [Impact factor: 6.198; Ranking: 23/196]  
  19. Chi-Sen Chang, Shen-Min Huang, Hui-Hsuan Lin, Huang SM Wu CC, Chau-Jong Wang*. Different expression of apoptotic proteins between HBV-infected and non-HBV-infected hepatocellular carcinoma. Hepato-gastroenterology. 54, 2061-2068, 2007. [Impact factor: 0.774; Ranking: 148/198]
  20. Tzu-Li Lin, Hui-Hsuan Lin, Chang-Che Chen, Ming-Cheng Lin, Ming-Chih Chou, Chau-Jong Wang*. Hibiscus sabdariffa extract reduces serum cholesterol in men and women. Nutrition Research. 27, 140-5, 2007. [Impact factor: 2.142; Ranking: 38/76]  
  21. Hui-Hsuan Lin, Jing-Hsien Chen, Wu-Hsien Kuo, Chau-Jong Wang*. Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chemico-Biological Interactions. 165, 59-75, 2007. [Impact factor: 2.967; Ranking: 75/260] (NSC91-2745-B-040-001)
  22. Cheng-Hsun Wu, Hui-Hsuan Lin, Fu-Pin Yan, Cheng-Hua Wu, Chau-Jong Wang*. Immunohistochemical Detection of Apoptotic Proteins, p53/Bax and JNK/FasL Cascade, in the Lung of Rats Exposed to Cigarette Smoke. Archives of Toxicology. 80, 328-36, 2006. [Impact factor: 5.215; Ranking: 6/85]
  23. Jing-Hsien Chen, Fen-Pi Chou, Hui-Hsuan Lin, Chau-Jong Wang*. Gaseous nitrogen oxide repressed benzo[a]pyrene-induced human lung fibroblast cell apoptosis via inhibiting JNK1 signals. Archives of Toxicology. 79, 694-704, 2005. [Impact factor: 5.215; Ranking: 6/85]
  24. Wu-Hsien Kuo, Jing-Hsien Chen, Hui-Hsuan Lin, Bi-Chiou Chen, Jeng-Dong Hsu, Chau-Jong Wang*. Induction of apoptosis in the lung tissue from rats exposed to cigarette smoke involves p38/JNK MAPK pathway. Chemico-Biological Interactions. 155, 31-42, 2005. [Impact factor: 2.967; Ranking: 75/260]
  25. Hui-Hsuan Lin, Hui-Pei Huang, Chi-Chou Huang, Jing-Hsien Chen, Chau-Jong Wang*. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Molecular Carcinogenesis. 43, 86-99, 2005. [Impact factor: 4.269; Ranking: 48/196]
  26. Chi-Sen Chang, Wei-Na Chen, Hui-Hsuan Lin, Cheng-Chung Wu, Chau-Jong Wang*. Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor kappaB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma. World Journal of Gastroenterology. 10, 2232-40, 2004. [Impact factor: 2.547; Ranking: 34/74]
  27. Jing-Hsien Chen, Tsui-Hwa Tseng, Yung-Chyan Ho, Hui-Hsuan Lin, Wea-Lung Lin, Chau-Jong Wang*. Gaseous nitrogen oxides stimulate cell cycle progression by retinoblastoma phosphorylation via activation of cyclins/Cdks. Toxicological Sciences. 76, 83-90, 2003. [Impact factor: 4.328; Ranking: 8/85]

  

期刊論文------研討會論文(近三年)

 

  1. Jing-Hsien Chen, Chau-Jong Wang, Chen-Chien Wang, Chia-Liang Lin, and Hui-Hsuan Lin*, 2012, Hibiscus sabdariffa leaf reduces the development of atherosclerosis via inhibition of LDL oxidation and foam cell formation. The 27th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  2. Jing-Hsien Chen, Jenn-Yuan Sheu, Pin-Quan Hou, Soi-Tong Ho, and Hui-Hsuan Lin*, 2012, Hibiscus sabdariffa leaf inhibits the growth of human prostate cancer LNCaP cells in vivo. The 27th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  3. Jing-Hsien Chen, Jenn-Yuan Sheu, Ting-Hsuan Wang, Liao-Shi Xian, Hui-Hsuan Lin*, 2012, Chemopreventive effects of Hibiscus sabdariffa Linne leaf on human melanoma A375 cells through cell cycle inhibition. The 27th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  4. Hui-Hsuan Lin, Ming-Der Shi, Chin-Hsun Hsu, Shih-Shu Lu, Jing-Hsien Chen*, 2012, Andrographolide enhances the sensitivity of human colorectal carcinoma Lovo cells toward the apoptosis of cisplatin. The 27th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  5. Hui-Hsuan Lin, Chin-Hsun Hsu, Yi-Han Han, Jing-Wei Lin, Tai-An Chiang, Jing-Hsien Chen*, 2012, Protocatechuic acid inhibits ultraviolet B-induced melanogenesis via down-regulation of p53/proopiomelanocortin expression in human epidermal keratinocytes. The 27th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  6. Jing-Hsien Chen, Jenn-Yuan Sheu, Chia-Liang Lin, Shu-Wen Hsuan, Chau-Jong Wang and Hui-Hsuan Lin*, 2012. Hibiscus sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo. Asia-Pacific Medical Laboratory Science Forum 2012, Taichung, R.O.C.
  7. Hui-Hsuan Lin, Jenn-Yuan Sheu, Chia-Liang Lin, Chau-Jong Wang and Jing-Hsien Chen*, 2012, Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-kB pathway and MMP-2 production by targeting RhoB activation. Asia-Pacific Medical Laboratory Science Forum 2012, Taichung, R.O.C.
  8. Chia-Liang Lin, Jing-Hsien Chen, Zhen-Jong Huang, Ying-Hua Hsu, Hui-Hsuan Lin*, 2013, Hibiscus abdariffa leaf polyphenolic extract induces apoptosis and autophagy of human prostate cancer Cells. The 28th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  9. Jing-Hsien Chen, Yu-Hsuan Chou, Huei-Yin Chen, Chia-Yu Chung, Hui-Hsuan Lin*, 2013,  Hibiscus sabdariffa leaf polyphenolic extract inhibits TNF-alpha-induced migration and proliferation of vascular smooth muscle cells. The 28th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  10. Shih-Shu Lu, Hui-Hsuan Lin, Cheng-Chin Hsu, Jing-Hsien Chen*, 2013, The inhibitory effects of Hibiscus sabdariffa leaf extract on UVB-induced expression of matrix metalloproteinases in human dermal fibroblast cells. The 28th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  11. Jing-Wei Lin, Hui-Hsuan Lin, Cheng-Chin Hsu, Jing-Hsien Chen*, 2013, The Inhibitory Effects of Hibiscus sabdariffa leaf extract on α-MSH induced melanogenesis in mouse melanoma B16 cells. The 28th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  12. Hui-Hsuan Lin, Hsin-Pei Lee, Jenn-Yuan Sheu, Jing-Hsien Chen*, 2013, Hibiscus sabdariffa leaf polyphenolic extract induces autophagy and apoptosis in human melanoma Cells. The 28th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  13. Ying-Hua Hsu, Jing-Hsien Chen, Ting-Hsuan Wang, Hui-Hsuan Lin*, 2013, Anti-atherosclerotic potential of Hibiscus sabdariffa leaf via inhibiting LDL oxidation and foam cell formation. International Conference and Exhibition on Nutraceuticals and Functional Foods 2013.
  14. Ting-Shuan Lee, Hui-Hsuan Lin, Jing-Wei Lin, Cheng-Chin Hsu, Jing-Hsien Chen*, 2013, Inhibitory effects of Hibiscus sabdariffa leaf extracts on melanogenesis in vitro and in vivo. International Conference and Exhibition on Nutraceuticals and Functional Foods 2013.
  15. Ming-Hsiang Lin, Chia-Liang Lin, Ming-Shih Lee, Ying-Hua Hsu, Jing-Hsien Chen, Hui-Hsuan Lin*, 2013, Effects of Hibiscus sabdariffa leaf polyphenolic extracts on human prostate cancer cell growth. The 2013 Annual Meeting of the Taiwan Society of Laboratory Medicine.
  16. Chia-Wen Lee, Hui-Hsuan Lin, Ming-Shih Lee, Jing-Hsien Chen*, 2013, Hibiscus sabdariffa leaf extract induces human melanoma cells death through autophagy and apoptosis pathway. The 2013 Annual Meeting of the Taiwan Society of Laboratory Medicine. 
  17. Chi-Ping Wang, Jing-Hsien Chen, Ming-Shih Lee, Ting-Hsuan Wang, Hui-Hsuan Lin*, 2013, Anti-atherosclerotic effects of Hibiscus sabdariffa leaf extracts. The 2013 Annual Meeting of the Taiwan Society of Laboratory Medicine.
  18. Hsin-Pei Lee, Hui-Hsuan Lin, Cheng-Chin Hsu, Jing-Hsien Chen*, 2014, The inhibitory effect of Murraya Paniculata extract on UVB-induced expression of matrix metalloproteinases in human dermal fibroblast cells. The 29th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  19. Huei-Yin Chen, Jing-Hsien Chen, Meng-Ying Tsai, Deng-Chi Huang, Hui-Hsuan Lin*, 2014, Hibiscus sabdariffa leaf extract inhibits human prostate cancer cell invasion involving the down-regulation of Akt/NF-kB Ppathway and MMP-9 production. The 29th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  20. Ying-Hua Hsu, Jing-Hsien Chen, Jia-Yu Wu, Ting-Hsuan Wang, Hui-Hsuan Lin*, 2014, Gossypetin induces autophagic cell death of human prostate cancer LNCaP cells in vitro and In vivo. The 29th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  21. Ting-Shuan Lee, Hui-Hsuan Lin, Jing-Hsien Chen*, 2014, Inhibitory effects of Lotus seedpod extract on melanogenesis in vitro and in vivo. The 40th Joint Annual Conference of Nutrition Society of Taiwan.
  22. Chi-Ping Wang, Jing-Hsien Chen, Ying-Hua Hsu, Hui-Hsuan Lin*, 2014, Inhibitory Effects of Hibiscus sabdariffa leaf extract on invasion in human prostate cancer LNCaP cells. The 31st World Congress of Biomedical Laboratory Science (IFBLS), Taipei, R.O.C.
  23. Ting Hsuan Wang, Jing-Hsien Chen, Wei-Yu Chang, Hui-Hsuan Lin*, 2015, Beta-cell protective effects of lotus seedpod in vitro and in vivo. The 30th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.  
  24. Deng Chi Huang, Jing-Hsien Chen, Ting Hsuan Wang, Ting Yu Su, Hui-Hsuan Lin*, 2015, The effect of lotus seedpod on metabolic syndrome. The 30th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.
  25. Ting Hsuan Wang, Jing-Hsien Chen, Deng Chi Huang, Ying-Hua Hsu, Hui-Hsuan Lin*, 2015, Gossypetin, a naturally occurring hexahydroxy flavone, induces human prostate cancer cell death, apoptosis and autophagy. The 41th Joint Annual Conference of Nutrition Society of Taiwan.